<div dir="ltr">Most recent IPATH newsletter.<br><br clear="all"><div><div dir="ltr" class="gmail_signature" data-smartmail="gmail_signature"><div dir="ltr"><div><div dir="ltr"><div><div dir="ltr"><div dir="ltr">-Michelle Thompson<br><br><div dir="ltr"><br></div></div></div></div></div></div></div></div></div><br><br><div class="gmail_quote"><div dir="ltr" class="gmail_attr">---------- Forwarded message ---------<br>From: <strong class="gmail_sendername" dir="auto">IPATH</strong> <span dir="auto"><<a href="mailto:elampley@health.ucsd.edu">elampley@health.ucsd.edu</a>></span><br>Date: Thu, Oct 6, 2022 at 9:24 AM<br>Subject: IPATH Quarterly Newsletter: October 2022<br>To: <<a href="mailto:mountain.michelle@gmail.com">mountain.michelle@gmail.com</a>><br></div><br><br><div class="msg-8510080881991890539"><u></u>
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<span class="m_-6403287255310138811mcnPreviewText" style="display:none;font-size:0px;line-height:0px;max-height:0px;max-width:0px;opacity:0;overflow:hidden">Read about IPATH's latest updates and collaborations </span>
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<h1 style="display:block;margin:0;padding:0;color:#222222;font-family:Helvetica;font-size:40px;font-style:normal;font-weight:bold;line-height:125%;letter-spacing:normal;text-align:center"><span style="font-family:helvetica neue,helvetica,arial,verdana,sans-serif"><strong><span style="color:#182b49"><span style="font-size:48px">Quarterly Newsletter</span></span></strong></span></h1>
<div style="text-align:justify">Each quarter, the Center for Innovative Phage Applications and Therapeutics (IPATH) aims to share the most relevant bacteriophage therapy news, publications and updates, as well as highlight researchers in the field and passionate advocates. </div>
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<div style="text-align:left"><font face="helvetica neue, helvetica, arial, verdana, sans-serif"><span style="font-size:32px">IPATH Stories</span></font></div>
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<div style="text-align:center"><span style="font-size:32px"><strong>NIH-Supported Phage Therapy Clinical Trial </strong></span><br>
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<div style="text-align:center"><a href="https://ucsd.us20.list-manage.com/track/click?u=229bb3861fe841bdbe5c4c921&id=1aabd6bdfe&e=9b19ce046e" style="color:#007c89;font-weight:normal;text-decoration:underline" target="_blank"><img alt="Pseudomonas Aeruginosa" height="193" src="https://www.nih.gov/sites/default/files/styles/featured_media_breakpoint-medium/public/news-events/news-releases/2022/20221004-pseudomonas-aeruginosa.png?itok=_tUiQwhv×tamp=1664878969" style="border:0px initial;width:250px;height:193px;margin:0px;outline:none;text-decoration:none" width="250"></a></div>
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<div style="text-align:left">IPATH is excited to share that the National Institutes of Health (NIH)-supported phage therapy clinical trial, titled <a href="https://ucsd.us20.list-manage.com/track/click?u=229bb3861fe841bdbe5c4c921&id=2026c81ddd&e=9b19ce046e" style="color:#007c89;font-weight:normal;text-decoration:underline" target="_blank">A Phase 1b/2 Trial of the Safety and Microbiological Activity of Bacteriophage Therapy in Cystic Fibrosis Subjects Colonized With <em>Pseudomonas aeruginosa</em></a>, has began this month under the leadership of IPATH Co-Director, Dr. Robert Schooley. This long-awaited trial plans to enroll 72 participants across 16 cystic fibrosis centers throughout the United States, including a site at UC San Diego. Participants in this trial will receive a single IV infusion of WRAIR-PAM-CF1, which contains four anti-<em>Pseudomonas</em> phages. Researchers will study the safety and microbiological activity of the phages in enrolled patients.<br>
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For more information on the trial please see the NIH <a href="https://ucsd.us20.list-manage.com/track/click?u=229bb3861fe841bdbe5c4c921&id=c5da9f1599&e=9b19ce046e" style="color:#007c89;font-weight:normal;text-decoration:underline" target="_blank">press release</a>, <a href="https://ucsd.us20.list-manage.com/track/click?u=229bb3861fe841bdbe5c4c921&id=9b21c4b095&e=9b19ce046e" style="color:#007c89;font-weight:normal;text-decoration:underline" target="_blank">ClinicalTrials.gov</a> or IPATH's <a href="https://ucsd.us20.list-manage.com/track/click?u=229bb3861fe841bdbe5c4c921&id=5817ab10e0&e=9b19ce046e" style="color:#007c89;font-weight:normal;text-decoration:underline" target="_blank">FAQs</a> on the trial.</div>
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<div style="text-align:center"><span style="font-size:32px"><strong>Dr. Elizabeth Kutter Visits IPATH</strong></span><br>
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<img alt="Betty Kutter and IPATH Lab" height="224" src="https://mcusercontent.com/229bb3861fe841bdbe5c4c921/_compresseds/69f07561-93dc-a741-626b-712a82f220e7.jpeg" style="border:0px initial;width:400px;height:224px;margin:0px;outline:none;text-decoration:none" width="400"></div>
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<div style="text-align:left">IPATH was honored to host Faculty Emeritus from The Evergreen State College, Dr. Elizabeth "Betty" Kutter, last month in San Diego. Dr. Kutter generously shared part of her well-known phage library, in person with IPATH, and was even able to give an exciting talk about her work throughout her 60-year career in phage research. Dr. Kutter's presentation was very well attended, but for those who were unable to join live, they can view the recorded talk on IPATH's website <a href="https://ucsd.us20.list-manage.com/track/click?u=229bb3861fe841bdbe5c4c921&id=905565f435&e=9b19ce046e" style="color:#007c89;font-weight:normal;text-decoration:underline" target="_blank">HERE</a>.<br>
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IPATH is very grateful for this amazing opportunity to connect and partner with such a celebrity of the phage research community. </div>
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<div style="text-align:center"><span style="font-size:32px"><strong>IPATH Collaborations in Brazil</strong></span><br>
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<img height="225" src="https://mcusercontent.com/229bb3861fe841bdbe5c4c921/images/13d2054e-5d33-00fc-bfd3-d72c3922888a.jpg" style="border:0px;width:300px;height:225px;margin:0px;outline:none;text-decoration:none" width="300"></div>
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This summer IPATH had two medical students, one from UC San Diego, Job Shiach, and one from the University of Missouri, Nicole Hitchcock, travel to Salvador, Brazil to conduct phage work with local researchers at SENAI-CIMATEC led by Dr. Roberto Badaró (SENAI-CIMATEC lab members and Nicole pictured above). Job worked in Brazil for one month, and Nicole has an entire year of work planned there. Job was nice enough to write about his experience in Brazil and share it with the IPATH community here. Below is Job's writing describing his experience in Brazil and how he got there. <br>
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<em>"I met Dr. Badaró at a dinner with the IPATH team after Dr. Schooley mentioned a potential opportunity to work with phage in Brazil. We spent the dinner talking about the culture, food and weather in San Diego and Salvador, Brazil, sailing, surfing, COVID infection, and of course, bacteriophage. At the end of the dinner Dr. Badaró shook my hand and said, "We’ll see you in Brazil”.<br>
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Two months later, I was in Salvador, Brazil at SENAI-CIMATEC meeting the team and touring the labs I’d spend the next month in. My goals for the summer were to train a small team of scientists on how to discover and characterize bacteriophage, help build collaborations with local hospitals to acquire infectious, drug-resistant bacteria of interest, discover phages, and learn to samba.<br>
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<img align="left" alt="Antibiogram of Klebsiella pneumoniae" height="196" hspace="10" src="https://mcusercontent.com/229bb3861fe841bdbe5c4c921/images/d1a0ab8a-f8f8-3e40-e4df-fe7f6124e02b.png" style="border:0px initial;width:200px;height:196px;margin:0px 10px 10px 0px;outline:none;text-decoration:none" vspace="10" width="200">When I arrived the team had already filled a fridge with dozens of environmental samples from across the city so we could hit the ground running. We started isolating Klebsiella pneumoniae phage because it is relatively easy to grow and a major cause of hospital-acquired infection in hospitals across Salvador. In our first batch we found eight unique bacteriophages! Thanks to Dr. Badaró we were also able to expedite IRB approval to collect bacteria from a local hospital to characterize their antibiotic resistance and also to test our phages against. To test antibiotic resistance, we do what’s called an antibiogram placing small paper discs each containing an antibiotic onto a petri dish containing the bacteria of interest. If the bacteria are killed by the antibiotic there will be a large, clear circle around the disc. If resistant, the bacteria will grow right up to the disc. Of the K. pneumoniae strains we received all of them were resistant to multiple antibiotics and one was resistant to every antibiotic we had available (pictured above). To test the phage against different strains of bacteria, we place a small drop (~2µl) of each phage in buffer around a similarly growing petri dish. Just in the first round of phage discovery we found 3 phages capable of killing that pan-drug resistant strain of K. pneumoniae we named CKP1.</em></div>
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<div style="text-align:left"><em>Now, I am back in San Diego along with a few of the bacteriophage found in Brazil to sequence them, and hopefully add to the repertoire of phages being used at UC San Diego to treat patients who need them. I am looking forward to returning to Salvador in the near future to continue this collaboration and learn to samba."</em></div>
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<div style="text-align:left"><font face="helvetica neue, helvetica, arial, verdana, sans-serif"><span style="font-size:32px">Faculty and Staff Profile</span></font></div>
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<div style="text-align:center"><img alt="Kanza Batool" height="356" src="https://mcusercontent.com/229bb3861fe841bdbe5c4c921/_compresseds/738adbdb-fdb7-2930-7489-8c7f5caea668.jpg" style="border:0px initial;width:300px;height:356px;margin:0px;outline:none;text-decoration:none" width="300"></div>
<div style="text-align:center"><span style="font-size:24px">Kanza Batool, Visiting Graduate Student</span><br>
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<p style="color:#182b49;font-family:Helvetica;font-size:14px;font-style:normal;font-weight:normal;text-align:left;margin:10px 0;padding:0;line-height:150%"><strong>Where is your hometown?</strong><br>
My hometown is Lahore, Pakistan<br>
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<strong>How did you first get involved with IPATH?</strong><br>
Actually my field of interest is dealing with phages. I am also doing phage research in my PhD. While I was applying for my scholarship, I saw a documentary with Dr. Pride <em>(W5: Using phage therapy to combat drug-resistant superbugs </em><a href="https://ucsd.us20.list-manage.com/track/click?u=229bb3861fe841bdbe5c4c921&id=6dbae6b94c&e=9b19ce046e" style="color:#007c89;font-weight:normal;text-decoration:underline" target="_blank"><em>https://www.youtube.com/watch?v=JasJ_63zqfw</em></a><em> )</em>. That inspired me a lot to get in touch with IPATH and have some new experiences and be a part of this innovative research. <br>
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<strong>What has surprised you most by working at IPATH and with phage therapy?</strong><br>
The most inspiring event is the story of Tom Patterson's recovery through phage therapy. I also have heard a lot about diabetic patients whose wounds were recovered by phage therapeutics. This is a true alternative therapy for many bacterial infections emerging nowadays, especially because of multidrug-resistant superbugs which are unable to be treated by traditional medication.<br>
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<strong>What projects are you currently working on?</strong><br>
Currently, I am working on two projects. One is dealing with the <em>Escherichia coli</em> phages, that can be used against ESBL <em>E. coli </em>to treat various infections, and checking their synergies with antibiotics. The other project is dealing with phage hunting for multidrug-resistant <em>Staphylococcus aureus </em>(MRSA)<em> </em>which is of high concern <em>.</em><br>
<br>
<strong>What is your favorite part about working at IPATH?</strong><br>
Most importantly, I love and enjoy working at IPATH because whatever I do, I always have in my mind that my little efforts can definitely contribute in saving someone’s life. This is my faith which always made me motivated toward my work and contributions day by day. Another best part of working here is synchronization of colleagues who are so cooperative which also contribute to my motivation all the time.<br>
<br>
<strong>What research goals do you hope to achieve in the future?</strong><br>
My main research goal is to implement whatever I learn here at IPATH at my home institute (Institute of Microbiology and Molecular Genetics, University of the Punjab, Lahore Pakistan). It could be an opportunity to enhance methodology and lab practices at my home institute that will help most in productive phage hunting. It will also be a great collaboration with IPATH so that we can also send our potential phages to IPATH to contribute in clinical trials.<br>
<br>
<strong>What is an interesting or fun fact about you?</strong><br>
Fun fact is that I never get tired of my work because I really enjoy working with phages. I also love to travel and explore new places. </p>
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<span style="font-size:12px"><span style="font-family:helvetica neue,helvetica,arial,verdana,sans-serif">Febrile Podcast | August 29, 2022</span></span></div>
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<span style="font-size:12px"><span style="font-family:helvetica neue,helvetica,arial,verdana,sans-serif">Nature | August 03, 2022</span></span></div>
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We have created a unique gift program where for $10,000 you can specifically direct your gift to phage hunting (for phages such as <em>Staphylococcus aureus, Pseudomonas aeruginosa, Enterococcus, Klebsiella, or E. coli </em>phages) and the naming of a new phage. <br>
<br>
If you are interested in contributing to our fight against antibiotic resistance, online gifts of any amount can be made through the button below, or by contacting our Executive Director of Development, Teri McIntyre, <a href="mailto:tlmcintyre@ucsd.edu" style="color:#007c89;font-weight:normal;text-decoration:underline" target="_blank">tlmcintyre@ucsd.edu</a>.
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